Ruhr-Universität Bochum

Neuroanatomie und Molekulare Hirnforschung

Adrii Klymenko


Ruhr-Universität Bochum
Institut für Anatomie
Abteilung für Neuroanatomie und Molekulare Hirnforschung


Evolutionary conserved mechanisms of regeneration from Hydra vulgaris to modern Homo sapiens with focus on the peripheral nerve regeneration

I focus my research on an evolutionary ancient organism, one of the very first to develop a nervous system on Earth, the Hydra vulgaris. This organism is a tiny fresh-water polyp, with high regenerative abilities and potential immortality, possesses a repertoire of small peptides, that orchestrate the Hydras’ development and resilience to injury. My objective is to test those peptides in models of peripheral nerve regeneration and identify the evolutionary basis of the common regenerative pathways, as well as to explore the ways of possible therapeutic implementation in the treatment of peripheral nerve disorders.


  • Klymenko, Andrii; Lutz, David (2022): Melatonin signalling in Schwann cells during neuroregeneration. In Front. Cell Dev. Biol. 10, p. 999322. DOI: 10.3389/fcell.2022.999322.
  • Stoyanova, Irina I.; Klymenko, Andrii; Willms, Jeannette; Doeppner, Thorsten R.; Tonchev, Anton B.; Lutz, David (2022): Ghrelin Regulates Expression of the Transcription Factor Pax6 in Hypoxic Brain Progenitor Cells and Neurons. In Cells 11 (5), p. 782. DOI: 10.3390/cells11050782.
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